| 摘要 |
The invention relates to a composition comprising an amino acid like structure carrying a sulfur moiety and a biologically acceptable carrier for inhibiting islet dysfunction and/or autoimmune disorders. The structure may be taurine, L-cysteine, L-methionine, or a combination of these. Conditions of islet dysfunction include insulitis, Type 1 diabetes (IDDM), Type 2 diabetes (NIDDM), mature onset diabetes of the young (MODY), and gestational diabetes. Autoimmune disorders include insulitis, Type 1 diabetes, rheumatoid arthritis, thyroiditis and pancreatitis. The composition can act to inhibit islet dysfunction through exerting anti-apoptotic or immunomodulatory activity. Methods are provided for inhibiting islet dysfunction and/or autoimmune disorders by administering an amino acid like structure carrying a sulfur moiety to an individual. |
