| 摘要 |
A method of diagnosing risk of development of cardiovascular disease in a patient during or following an episode of depression comprises identifying in said patient a statistically significant increased level of platelet membrane glycoprotein receptors, in particular GPIb receptors, for cytoadhesive plasma proteins relative to a reference range for a normal population. The increased level of GPIb receptor is independent of platelet turnover, generic differences in expression of the Kozac sequence polymorphism of the GpIb alpha gene and any smoking habit in the patient. This increase in receptors associated with platelet adhesion may render depressed patients more susceptible to thrombosis and may explain the increased incidence of cardiovascular disease in depressed patients. |
