IMPROVED TREATMENT FOR ACUTE PHYSICAL INSULT TO THE CENTRAL NERVOUS SYSTEM

摘要

A method of promoting functional recovery and reducing oxidative stress and inflammation following an acute physical insult to the central nervous syste m, comprising administering to a mammalian patient which has suffered an acute physical insult to the central nervous system an initial dose of L-2- oxothiazolidine-4-carboxylate ("OTC") or a variant thereof is disclosed. Thi s method preferably further includes the step of administering a number of subsequent doses of OTC or a variant thereof at subsequent time periods. Als o provided is a use of OTC or a variant thereof in the preparation of a medicament useful in reducing inflammation in the central nervous system and promoting the functional recovery of a mammalian patient which has suffered an acute physical insult to the central nervous system, such as neurotrauma, stroke or aneurysm.