Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
申请公布号
WO0214482(A2)
申请公布日期
2002.02.21
申请号
WO2001GB03642
申请日期
2001.08.14
申请人
BIOTICA TECHNOLOGY LIMITED;PETKOVIC, HRVOJE;KENDREW, STEVEN, GARY;LEADLAY, PETER, FRANCIS
发明人
PETKOVIC, HRVOJE;KENDREW, STEVEN, GARY;LEADLAY, PETER, FRANCIS