发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 4-METHYL-BIPHENYL-DERIVATEN |
摘要 |
<p>The subject-matter of the invention is a process for the preparation of substituted 4-methylbiphenyls of general formula:in which R is a cyano group or a protected tetrazolyl group of formula:in which R1, situated at the 1 or 2 position of the tetrazolyl group, is a protective group, characterized in that a halobenzene of formula:in which Hal is a halogen atom and R has the same meaning as above, is reacted with a p-tolylmagnesium halide in the presence of a linear or branched polyether and of a catalyst comprising a transition metal.</p> |
申请公布号 |
DE69709773(D1) |
申请公布日期 |
2002.02.21 |
申请号 |
DE1997609773 |
申请日期 |
1997.09.17 |
申请人 |
SANOFI-SYNTHELABO, PARIS |
发明人 |
ALAMI, MOUAD;CAHIEZ, GERARD;CASTRO, BERTRAND;DORMOY, JEAN-ROBERT;RIGUET, ERIC |
分类号 |
B01J31/22;C07B61/00;C07C253/30;C07C255/50;C07D257/04;(IPC1-7):C07C253/30 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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