发明名称 |
DIAGNOSIS AND TREATMENT OF TUMOR-SUPPRESSOR ASSOCIATED DISORDERS |
摘要 |
Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSKC1 and detecting the level of TSLC1 in the proliferating cell. <i>TSLC1</i> is a single gene whose expression is reduced or absent in A549 and some other NSCLC, hepatocellular carcinoma and pancreatic cancer cell lines. It has further been discovered that <i>TSLC1</i> expression or suppression is perfectly correlated with promoter methylation state. Restoration of <i>TSLC1</i> expression to normal or higher levels is sufficient by itself to suppress tumor formation. The invention further provides methods of treating such disorders by contacting cells of a patient suffering from the disorder with a therapeutically effective amount of a reagent that modulates TSLC1 level in the proliferating cells.
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申请公布号 |
WO0214557(A1) |
申请公布日期 |
2002.02.21 |
申请号 |
WO2001US25690 |
申请日期 |
2001.08.15 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDECINE;REEVES, ROGER, HARPER;YOSHINORI, MURAKAMI |
发明人 |
REEVES, ROGER, HARPER;YOSHINORI, MURAKAMI |
分类号 |
A61K38/17;C12Q1/68;G01N33/50;G01N33/574;(IPC1-7):C12Q1/68;G01N33/53;G01N33/564;G01N33/48;A61K39/00;A01N43/04 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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地址 |
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