摘要 |
The use of a polypeptide capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2 but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptide preferably comprises a PH domain which binds specifically to one of PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The PH domain preferably has at least five of the six residues of a <u>P</u>utative <u>P</u>tdIns(3,4,5)P3 <u>B</u>inding <u>M</u>otif (PPBM). |
申请人 |
MEDICAL RESEARCH COUNCIL;DOWLER, SIMON;CAMPBELL, DAVID;GRAY, ALEXANDER;DOWNES, PETER;ALESSI, DARIO |
发明人 |
DOWLER, SIMON;CAMPBELL, DAVID;GRAY, ALEXANDER;DOWNES, PETER;ALESSI, DARIO |