发明名称 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
摘要 |
Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administering the RNA-loaded antigen-presenting cells to a patient, tumor formation or pathogen infections can be treated or prevented. Alternatively, the RNA-loaded cells can be used as stimulator cells in the ex vivo. expansion of CTL. Such CTL can then be used in a variation of conventional adoptive immunotherapy techniques.
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申请公布号 |
US2002018769(A1) |
申请公布日期 |
2002.02.14 |
申请号 |
US20010875264 |
申请日期 |
2001.06.07 |
申请人 |
NAIR SMITA K.;BOCZKOWSKI DAVID J.;GILBOA ELI |
发明人 |
NAIR SMITA K.;BOCZKOWSKI DAVID J.;GILBOA ELI |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K35/56;A61K39/00;A61K48/00;A61P35/00;C07K14/47;C07K14/705;C07K14/77;C12N5/078;C12N5/10;C12N15/62;C12Q1/02;(IPC1-7):A61K48/00;C12N5/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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