发明名称 |
Novel diagnostic screens type 1 diabetes (IDDM) |
摘要 |
The present invention features methods for diagnosing insulin-dependent diabetes mellitus (IDDM) in a test subject, for example a subject at risk of developing IDDM, which involve detecting hyper-responsive Ca2+ mobilization in cells obtained from the test subject. Hyper-responsive Ca2+ mobilization can be detected in cells contacted with a stimulatory agent, preferably in cells contacted with a potentiating agent and a stimulatory agent. Methods of the present invention include comparing Ca2+ mobilization in cells from the test subject to Ca2+ mobilization in cells from a control subject. The present invention further features kits for use in the detection of IDDM.
|
申请公布号 |
US2002018987(A1) |
申请公布日期 |
2002.02.14 |
申请号 |
US20010972305 |
申请日期 |
2001.10.05 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY |
发明人 |
CORKEY BARBARA E.;HUSNI NICHOLAS R. |
分类号 |
G01N33/50;(IPC1-7):C12Q1/00;G01N33/48 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|