| 摘要 |
Disclosed is a single nucleotide polymorphism (SNP) associated with colon cancer, hypertension, atherosclerotic peripheral vascular disease due to hypertension, cerebrovascular accident due to hypertension, cataracts due to hypertension, hypertensive cardiomyopathy, myocardial infarction due to hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, atherosclerotic peripheral vascular disease due to non-insulin dependent diabetes mellitus, cerebrovascular accident due to non-insulin dependent diabetes mellitus, ischemic cardiomyopathy, ischemic cardiomyopathy with non-insulin dependent diabetes mellitus, myocardial infarction due to non-insulin dependent diabetes mellitus, atrial fibrillation without valvular disease, alcohol abuse, alcoholic cirrhosis, anxiety, asthma, chronic obstructive pulmonary disease, cholecystectomy, degenerative joint disease, end stage renal disease and frequent de-clots, end stage renal disease due to focal segmental glomerular sclerosis, end stage renal disease due to insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, and seizure disorder. Also disclosed are methods for using the SNP to determine susceptibility to these diseases; nucleotide sequences containing the SNP; kits for determining the presence of the SNP; and methods of treatment or prophylaxis based on the presence of the SNP. |
