发明名称 |
Mutations of the mdr1 p-glycoprotein that improve its ability to confer resistance to chemotherapeutic drugs |
摘要 |
The present invention provides mutant P-glycoprotein polypeptides that confer increased resistance to certain chemotherapeutic drugs relative to wild-type P-glycoprotein or P-glycoprotein having a glycine to valine substitution at position 185, and nucleic acid molecules encoding the same. The invention also provides antibodies that specifically bind mutant P-glycoproteins. The invention further provides methods for the diagnosis and treatment of conditions associated with P-glycoprotein-mediated multidrug resistance. |
申请公布号 |
AU8312701(A) |
申请公布日期 |
2002.02.13 |
申请号 |
AU20010083127 |
申请日期 |
2001.08.01 |
申请人 |
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
ADAM RUTH;IGOR RONINSON |
分类号 |
A61K38/00;C07K14/705;C07K16/28;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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