发明名称 |
Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient |
摘要 |
To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 mu g/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action. |
申请公布号 |
AU7669401(A) |
申请公布日期 |
2002.02.13 |
申请号 |
AU20010076694 |
申请日期 |
2001.07.27 |
申请人 |
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED |
发明人 |
TORU KIMURA;KAORU KIKUCHI;KAZUO KUMAGAI;NORIO HOSOTANI;AKIYOSHI KISHINO |
分类号 |
A61P21/00;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P27/06;A61P43/00;C07D311/78;C07D311/86;C07D493/04 |
主分类号 |
A61P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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