发明名称 |
Process for the cyanation of aldehydes |
摘要 |
A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si-CN bond or a C-(C=O)-CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride. |
申请公布号 |
AU7574001(A) |
申请公布日期 |
2002.02.13 |
申请号 |
AU20010075740 |
申请日期 |
2001.08.01 |
申请人 |
KING'S COLLEGE LONDON, AN INSTITUTION INCORPORATED BY ROYAL CHA;NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS |
发明人 |
MICHAEL NORTH;YURI BELOKON |
分类号 |
B01J31/22;B01J31/18;C07B53/00;C07B61/00;C07C253/00;C07C255/14;C07C255/15;C07C255/38 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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