发明名称 |
Methods of treating autoimmune diseases with a CD86-specific immunotoxin |
摘要 |
A method for treating autoimmune diseases comprising administering to a patient in need of such treatment a therapeutically effective amount of an immunotoxin comprising an anti-human CD86 monoclonal antibody IG10H6D10 as deposited in the ECACC collection under No. 95060210 or a humanized antibody, a single-chain antibody or fragments and specificity of said monoclonal antibody, coupled to a toxin or active fragments thereof wherein the binding of the immunotoxin to CD86 results in the killing of the CD86 expressing cell.
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申请公布号 |
US6346248(B1) |
申请公布日期 |
2002.02.12 |
申请号 |
US19990373474 |
申请日期 |
1999.08.12 |
申请人 |
INNOGENETICS N.V. |
发明人 |
DE BOER MARK;DE GAST G. C. |
分类号 |
C12N15/02;A61K39/395;A61K47/48;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/02;C12P21/08;C12R1/91;(IPC1-7):A61K39/395;C07K16/28 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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