发明名称 |
Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles |
摘要 |
A process for solubilizing in water and in aqueous vehicles sparingly water-soluble pharmaceutically active substances, comprising the following operations: 1) forming a complex of the pharmaceutically active substance with a pharmaceutically acceptable non-ionic polymer capable of forming complexes with the substance, and isolating the complex in solid form; 2) dissolving again the thus obtained complex in an aqueous medium by means of a pharmaceutically acceptable surfactant. The method allows to markedly increase the water-solubility of pharmaceutically active organic compounds which are intrinsically poorly or negligibly soluble in water, in order to obtain preparations that are stable in aqueous solution and contain therapeutically and commercially useful concentrations of active ingredient.
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申请公布号 |
US6346273(B1) |
申请公布日期 |
2002.02.12 |
申请号 |
US20000463331 |
申请日期 |
2000.01.21 |
申请人 |
FARMIGEA S.P.A.;MARCO FABRIZIO SAETTONE;BORIS GIANNACCINI |
发明人 |
SAETTONE MARCO FABRIZIO;GIANNACCINI BORIS;BOLDRINI ENRICO;BIANCHINI PIETRO |
分类号 |
A61K9/00;A61K9/08;A61K31/198;A61K31/335;A61K31/352;A61K31/357;A61K31/506;A61K31/5415;A61K31/542;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/40;A61K47/44;A61K47/48;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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