发明名称 |
Antibodies that bind human haemopoietic maturation factor |
摘要 |
Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
|
申请公布号 |
US6346246(B1) |
申请公布日期 |
2002.02.12 |
申请号 |
US19990333033 |
申请日期 |
1999.06.15 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
KIRKNESS EWEN F.;ADAMS MARK D.;OLSEN HENRIK S.;ROSEN CRAIG A. |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61K39/395;A61K48/00;A61P7/00;A61P7/06;A61P25/00;A61P35/02;A61P43/00;C07H21/04;C07K14/47;C07K14/475;C07K16/18;C12N1/21;C12N5/10;C12P21/02;C12P21/08;C12Q1/68;(IPC1-7):A61K39/395;C07K16/00;C07K16/24 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|