| 摘要 |
<p>A dowel (800) is provided by obtaining a plug from the shaft (diaphysis) of various long bones. The dowel (800) has an intra-medullary canal (30), which can be packed with any of a variety of osteogenic materials. The dowel (800) has a cortical surface (10) into which an instrument attachment hole (15) may be machined and onto which an alignment mark (16) may be inscribed for proper orientation of the intra-medullary canal (30). The dowel (800) has a chamfered insertion end (822) and has improved biomechanical and vertebral fusion induction properties as compared to standard dowels known in the art. Also disclosed herein are various implants that comprise a plurality of holes (810) to aid in the delivery of biologically active substances associated with said implants. The implant (800) may further be infused, embedded soaked or coated, or combinations thereof, with biologically active substances selected from growth factors, bone morphogenetic proteins, cells, antibiotics, proteins, peptides, and nucleic acids.</p> |
