COMPOSITIONS FOR INDUCING SELF-SPECIFIC ANTI-IgE ANTIBODIES AND USES THEREOF

摘要

The invention relates to compositions for the induction of anti-IgE antibodies in order to prevent or inhibit IgE-mediated disorders. The compositions contain carriers foreign to the immunized human or animal coupled to polypeptides containing fragments of the IgE molecule. The fragment of the IgE molecule includes the constant CH1 and/or the CH4 domain of the IgE molecule. The composition is administered to humans or animals in order to induce antibodies specific for endogenous IgE antibodies. These induced anti-IgE antibodies reduce or eliminate the pool of free IgE in the serum. Since many allergic diseases are mediated by IgE, IgE-mediated disorders are ameliorated in treated mammals.