| 摘要 |
The present invention relates to a new, simple, and easy process for preparing cephalosporin antibiotics of the following sub-formulas (I), such as cefixime. The process comprises acylating a 7-amino cephalosporanic acid derivative of the following sub-formulas (III) with a crystalline aminothiazole compound of the following sub-formulas (II): wherein R1 and R2 are the same or different and independently represent H, a C1-4 alkyl or C3-5 cycloalkyl group, and the acid in the acid addition salt represents an inorganic acid, such as hydrochloric acid, or an organic acid, such as formic acid or acetic acid.
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