3-SUBSTITUTED ISOQUINOLIN-1-YL DERIVATIVES

摘要

Squaric acid derivatives of formula (1) are described: wherein R<1> is a hydrogen atom or a C1-6alkyl group; L<1> is a covalent bond or a linker atom or group; Alk<1> is an optionally substituted aliphatic chain; n is zero or the integer 1; R<2> is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group; Alk is a chain (a), (b), (c) or (d)in which R is a carboxylic acid (-CO2H) or a derivative or biostere thereof; Ar<2> is an optionally substituted aromatic or heteroaromatic linking group; L<2> is a covalent bond or a linker atom or group; R<16> is the group -L<3>(Alk<2>)tL<4>R<20> in which L<3> and L<4> which may be the same or different is each a covalent bond or a linker atom or group, t is zero or the integer 1, Alk<2> is an optionally substituted aliphatic or heteroaliphatic chain and R<20> is an optionally substituted aromatic or heteroaromatic group. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders including the inappropriate growth or migration of cells.