| 摘要 |
<p>A D- or L-lyxofuranosyl benzimidazole compound selected from the given formulae wherein; R2, R4, R5, R6, and R7 are independently the same or different and independently selected from -H, -F, -Cl, -Br, -I, -NO2, -N(R8)2, -OR8, -SR12, and -CF3, wherein R8 is independently -H or an alkyl group having 1-6 carbon atoms and wherein R12 is independently -H or a hydrocarbyl group having 1-10 carbon atoms; and R9, R1O and R" are independently the same or different and are H or a hydroxyl protecting group; anomeric, optical, and conformational isomers thereof; and, pharmaceutically acceptable salts and prodrug derivatives thereof with the proviso that, for beta-D and alpha-D compounds in which both R4 and R7 are H and both of R5 and R6 are Cl, R2 is not H. The compounds is useful in treating viral infection.</p> |
