CDT6 CAN INHIBIT ANGIOGENESIS AND TUMOR GROWTH, AND CAN INDUCE OR ENHANCE THE FORMATION OF STRUCTURES CONTAINING COLLAGEN V

摘要

In spite of the classification of CDT6 as a nonangiopoietin member of the fibrinogen domain containing superfamily, we have demonstrated that CDT6 has a potent effect on angiogenesis and tumor growth. CDT6 is capable of inhibiting at least in part angiogenesis. The invention provides the use of this novel angiogenesis antagonist in the treatment of diseases, preferably cancers that form solid tumors.