发明名称 |
PROCESS FOR MANUFACTURE OF 1-DEAMINO-8-D-ARGININE VASOPRESSIN |
摘要 |
<p>A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R1)-Tyr-Phe-Gln-Asn-Cys(R2)-Pro-OH (SEQ ID NO: 1), where R1 and R2 are sulfhydryl-protecting groups, with the dipeptide (R3)-D-Arg(HCl)-Gly-NH2, where R3 is an acid-sensitive amino-protecting group, to form Mpa(R1)-Tyr-Phe-Gln-Asn-Cys(R2)-Pro-D-Arg(HCl)-Gly-NH2 (SEQ ID NO: 1), which is oxidized with iodine in a protic solvent. The reaction mixture containing the oxidized product can be purified by ion exchange chromatography on a cation exchange resin equilibrated with acid. Also disclosed is high-purity DDAVP obtained by this process and its use for treating diurea.</p> |
申请公布号 |
GR3036935(T3) |
申请公布日期 |
2002.01.31 |
申请号 |
GR20010401803T |
申请日期 |
2001.10.18 |
申请人 |
FERRING B.V. |
发明人 |
LARSSON, BO AKE KRISTER;MELLBRAND, THOMAS BJOERN;MOERNSTAM, EWA MARIA BIRGITTA;ROSCHESTER, JAN ANDERS INGEMAR;SKOELDBAECK, JAN-AKE |
分类号 |
A61K38/04;A61K38/00;A61K38/11;A61P7/10;C07K1/107;C07K7/16;(IPC1-7):C07K7/16 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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