发明名称 |
CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO[1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES |
摘要 |
Disclosed are compounds of formula (I), where R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
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申请公布号 |
WO0123387(A3) |
申请公布日期 |
2002.01.24 |
申请号 |
WO2000US26887 |
申请日期 |
2000.09.29 |
申请人 |
NEUROGEN CORPORATION;PFIZER INC.;DARROW, JAMES, W.;DE LOMBAERT, STEPHANE;BLUM, CHARLES;TRAN, JENNIFER;GIANGIORDANO, MARK;GRIFFITH, DAVID, ANDREW;CARPINO, PHILIP, ALBERT |
发明人 |
DARROW, JAMES, W.;DE LOMBAERT, STEPHANE;BLUM, CHARLES;TRAN, JENNIFER;GIANGIORDANO, MARK;GRIFFITH, DAVID, ANDREW;CARPINO, PHILIP, ALBERT |
分类号 |
G01N33/50;A61K31/155;A61K31/427;A61K31/496;A61K31/519;A61K31/53;A61K31/64;A61K31/702;A61K45/00;A61P3/04;A61P3/06;A61P3/10;A61P9/04;A61P9/12;A61P15/00;A61P25/00;A61P25/04;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P29/02;A61P43/00;C07D487/04;G01N33/15;G01N33/566;(IPC1-7):C07D487/04;A61P9/00 |
主分类号 |
G01N33/50 |
代理机构 |
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