USE OF 2 alpha -METHYL-19-NOR-20(S)-1 alpha ,25-DIHYDROXYVITAMIN D>3< TO INCREASE BONE STRENGTH

摘要

This invention provides pharmaceutical uses for 2 alpha -methyl-19-nor-20(S)-1 alpha ,25-dihydroxyvitamin D>3<. This compounds is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment of diseases where bone formation is desired, particularly osteoporosis. This compound also exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.