| 摘要 |
The present invention is directed to the sue of at least one thyroid hormone compound or thyroid hormone-like agonist compound in the preparation of a topical medicament for the treatment of a dermatological condition affecting the dermis. The thyroid hormone compound or the thyroid hormone-like agonist compound binds to TR-.alpha. or TR-.beta. with an equilibrium dissociation constant, Kd, of less than 5 x 10-6 M. The invention is also directed to a composition for treating a dermatological conditions affecting the dermis an d to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating such a condition. Use of at least one thyroid hormone or thyroid hormone-like agoni st compound in the preparation of a topical medicament for the pre-treatment of skin in dermatological surgery is also provided.
|
