发明名称 |
High purity preparation of fluorinated 1,3-dicarbonyls using BDM (bis-fluoroxydifluoromethane) |
摘要 |
<p>A process for providing an α-fluorinated-β-dicarbonyl includes electrophilically fluorinating a β-dicarbonyl with bis-fluoroxydifluoromethane in the presence of an acid to provide the α-monofluorinated-β-dicarbonyl. The acid is preferably hydrofluoric acid. Preferred β-dicarbonyls include methyl-3-oxopentanoate and ethyl-4,4,4-trifluoroacetoacetate. The process can limit radical impurity byproducts to no more than 4% in some cases, and less than 0.5% in other cases. Theoretical yields of 95% α-monofluorinated-β-dicarbonyl are possible in some cases.</p> |
申请公布号 |
EP1174415(A1) |
申请公布日期 |
2002.01.23 |
申请号 |
EP20010117027 |
申请日期 |
2001.07.12 |
申请人 |
AIR PRODUCTS AND CHEMICALS, INC. |
发明人 |
CASTEEL, WILLIAM JACK, JR.;SYVRET, ROBERT GEORGE;BAILEY, WADE H., III |
分类号 |
C07B61/00;C07C45/63;C07C67/307;C07C69/716;(IPC1-7):C07C67/307 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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