发明名称 |
Integrative protein-DNA cochleate formulations and methods for transforming cells |
摘要 |
An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.
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申请公布号 |
US6340591(B1) |
申请公布日期 |
2002.01.22 |
申请号 |
US19980210578 |
申请日期 |
1998.12.14 |
申请人 |
UNIVERSITY OF MARYLAND;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
MARGOLIS DAVID;GOULD-FOGERITE SUSAN;MANNINO RAPHAEL JAMES |
分类号 |
A61K9/127;A61K48/00;C07K14/015;C12N15/864;C12N15/88;C12N15/90;(IPC1-7):C12N15/63;C07H21/04;C07K14/00 |
主分类号 |
A61K9/127 |
代理机构 |
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