发明名称 |
IMMUNOSTIMULATORY NUCLEIC ACIDS |
摘要 |
The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25 % T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/or greater than 50 % c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
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申请公布号 |
WO0122972(A3) |
申请公布日期 |
2002.01.17 |
申请号 |
WO2000US26383 |
申请日期 |
2000.09.25 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;COLEY PHARMACEUTICAL GMBH |
发明人 |
KRIEG, ARTHUR, M.;SCHETTER, CHRISTIAN;VOLLMER, JOERG |
分类号 |
C12N15/09;A23L;A23L1/30;A61K;A61K9/20;A61K9/48;A61K31/00;A61K31/7088;A61K31/7125;A61K35/12;A61K35/76;A61K38/00;A61K39/00;A61K39/08;A61K39/085;A61K39/102;A61K39/106;A61K39/108;A61K39/145;A61K39/21;A61K39/245;A61K39/39;A61K39/395;A61K45/00;A61K45/06;A61K48/00;A61P;A61P1/00;A61P1/16;A61P1/18;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P17/00;A61P19/00;A61P25/00;A61P27/02;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P37/04;A61P37/08;C12N5/06;(IPC1-7):A61K31/708 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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