发明名称 |
Method for finding nucleotide synthesis inhibitors having fewer side effects |
摘要 |
The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a mammal. The concentration of the nucleotide synthesis inhibitor in the blood of the mammal is observed and it is determined whether the nucleotide synthesis inhibitor has a half-life which is shorter than that of N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide. The invention also relates to a method of using nucleotide synthesis inhibitors in the treatment of immunological diseases.
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申请公布号 |
US2002006381(A1) |
申请公布日期 |
2002.01.17 |
申请号 |
US20000734588 |
申请日期 |
2000.12.13 |
申请人 |
LINDNER JURGEN;HAASE BURKHARD |
发明人 |
LINDNER JURGEN;HAASE BURKHARD |
分类号 |
G01N33/48;A61K31/275;A61P37/00;G01N33/15;G01N33/50;(IPC1-7):A61K31/785;A61K49/00 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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