NOVEL METHODS AND COMPOSITIONS INVOLVING OPIOIDS AND ANTAGONISTS THEREOF

摘要

Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea. Figures 2A aand 2B are graphical representations of studies on the inhibition of nausea and vomiting employing methods according to an embodiment of the present invention,