| 发明名称 |
Methods for the identification of compounds useful for the treatment of disease states mediated by Prostaglandin D2 |
| 摘要 |
<p>The present invention relates to the discovery that PGD2 is the natural ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for therapeutic compounds useful in the treatment of PGD2-related disorders such as allergy, asthma and inflammation. Appropriate assay methodology is also disclosed.</p> |
| 申请公布号 |
EP1170594(A2) |
申请公布日期 |
2002.01.09 |
| 申请号 |
EP20010305857 |
申请日期 |
2001.07.06 |
| 申请人 |
PFIZER PRODUCTS INC. |
发明人 |
BAUER, PAUL HAROLD;CENG, JOHN BIN;GLADUE, RONALD PAUL;LI, BAIYONG;NEOTE, KULDEEP SINGH;ZHANG, JIANSU |
| 分类号 |
G01N33/50;A61K31/192;A61K31/343;A61K31/381;A61K31/4166;A61K31/428;A61K31/5575;A61K31/575;A61K45/00;A61P9/00;A61P9/10;A61P11/06;A61P11/08;A61P17/00;A61P17/04;A61P17/06;A61P17/10;A61P19/02;A61P25/04;A61P25/20;A61P29/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/531;G01N33/564;G01N33/566;G01N33/88;G01N37/00;(IPC1-7):G01N33/88 |
主分类号 |
G01N33/50 |
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