发明名称 |
NOVEL ENTEROKINASE CLEAVAGE SEQUENCES |
摘要 |
Novel enterokinase cleavage sequences are provided. Also disclosed are metho ds for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion constru ct on a solid substrate. Preferred embodiments of the present invention show rates of cleavage up to thirty times that of the known enterokinase cleavage substrate (Asp)4-Lys-Ile.
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申请公布号 |
CA2408630(A1) |
申请公布日期 |
2001.12.27 |
申请号 |
CA20012408630 |
申请日期 |
2001.06.19 |
申请人 |
DYAX CORP. |
发明人 |
LADNER, ROBERT CHARLES;LEY, ARTHUR CHARLES;LUNEAU, CHRISTOPHER JON |
分类号 |
G01N33/53;C07K7/06;C07K14/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12N15/09;C12P21/02;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/566;(IPC1-7):C12N15/54;C07K14/47;C12N15/62;C12N15/63 |
主分类号 |
G01N33/53 |
代理机构 |
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