| 摘要 |
The present invention generally relates to cell growth modulators, methods o f screening for such modulators and methods of using such modulators. In particular, the present invention provides a method of identifying a modulat or of cell growth, which method comprises: a) assessing activity of a site- specific DNA recombinase or a type I DNA topoisomerase in the presence of a test substance; b) assessing activity of said site-specific DNA recombinase or said type I DNA topoisomerase in the absence of said test substance; and c) comparing said activities assessed in steps a) and b), whereby a difference in said activity assessed in step a) and said activity assessed in step b) indicates that said test substance modulates cell growth. Peptide cell growt h inhibitors and methods of using such inhibitors in treating certain diseases or disorders, e.g., tumor, cancer and bacterial infection, are also provided .
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