发明名称 |
OSTEOCLAST SECRETED CHEMOKINE AND USES THEREOF |
摘要 |
The present invention demonstrates the biological function of a newly identified osteoclast-secreted protein. This protein, mim-1, has sequence homology with but is distinct from a previously identified neutrophil chemokine protein. Mim-1 may be a key signaling protein secreted by osteoclast that regulates recruitment and/or differentiation of osteoblast and osteoclast precursor cells. This protein may also serve to maintain osteoclasts in a relatively inactive state prior to secretion. This mechanism is essential for regulating the mass and structural integrity of bone. This protein or an analog and/or antagonists of this protein will have potential therapeutic potential in the treatment of a variety of pathological bone diseases including osteoporosis and metastatic bone diseases.
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申请公布号 |
WO0197833(A1) |
申请公布日期 |
2001.12.27 |
申请号 |
WO2001US19575 |
申请日期 |
2001.06.19 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
WILLIAMS, JOHN, P.;MCDONALD, JAY, M.;MCKENNA, MARGARET, A. |
分类号 |
A61K38/17;A61K38/19;(IPC1-7):A61K38/16;A61K38/18 |
主分类号 |
A61K38/17 |
代理机构 |
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地址 |
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