Process for preparing tert-alkyl ester from carboxylic acid

摘要

A process for preparing a tert-alkyl carboxylic acid ester represented by the formula (III):wherein R1 is an organic group; and each of R2 and R3 is independently an alkyl group having 1 to 4 carbon atoms, comprising reacting a carboxylic acid represented by the formula (I):wherein R1 is as defined above, with a vinylidene compound represented by the formula (II):wherein R2 and R3 are as defined above, in the presence of a phosphorus halide. The tert-alkyl carboxylic acid ester can be used as intermediates for pharmaceuticals such as antibiotics.