发明名称 Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
摘要 This invention pertains to solid-phase oligosynthesis, and more particularly to universal solid supports for solid-phase oligonucleotide synthesis, methods for their preparation, and methods for their use. One aspect of the invention pertains to a method for the preparation of a universal solid support suitable for use in solid-phase oligosynthesis, which method comprises the steps of: (a) reacting a pendant functional group (e.g., -NH2) of a solid support (e.g., CPG) with a linker reagent (e g., oxalyl chloride), thereby forming a pendant linker group (e.g., -C(=O)Cl); (b) removing at least a portion of excess unreacted linker reagent by evaporation (e.g., using a rotavapor apparatus); and, (c) reacting said pendant linker group with a cyclic reagent (e.g., protected inosine), thereby forming a pendant cyclic group.
申请公布号 AU7271401(A) 申请公布日期 2001.12.24
申请号 AU20010072714 申请日期 2001.06.12
申请人 GENSET 发明人 VIKTOR KUMAREV
分类号 C07H19/167;C07B61/00;C07H19/16;C07H21/00;C07H21/04;C08G63/48;C08G63/91 主分类号 C07H19/167
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