| 发明名称 |
Heteroarylalkanoic acids as integrin receptor antagonists |
| 摘要 |
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the alpha<SUB>V</SUB>beta<SUB>3 </SUB>and/or the alpha<SUB>V</SUB>beta<SUB>5 </SUB>integrin without significantly antagonizing the IIb/IIIa or alpha<SUB>V</SUB>beta<SUB>6 </SUB>integrin. |
| 申请公布号 |
AU6987601(A) |
申请公布日期 |
2001.12.24 |
| 申请号 |
AU20010069876 |
申请日期 |
2001.06.15 |
| 申请人 |
PHARMACIA CORPORATION;SCRINIVASAN RAJ NAGARAJAN;ISH KUMAR KHANNA;MICHAEL B. TOLLEFSON;SCOTT B. MOHLER;BARBARA CHEN;MARK RUSSELL;BALEKUDRU DEVADAS;THOMAS D PENNING;LORI A. SCHRETZMAN;DALE P. SPANGLER;MARK LAURENCE BOYS;NIZAL SAMUEL CHANDRAKUMAR;HWANG-FUN LU |
发明人 |
SCRINIVASAN RAJ NAGARAJAN;ISH KUMAR KHANNA;MICHAEL B. TOLLEFSON;SCOTT B. MOHLER;BARBARA CHEN;MARK RUSSELL;BALEKUDRU DEVADAS;THOMAS D PENNING;LORI A. SCHRETZMAN;DALE P. SPANGLER;MARK LAURENCE BOYS;NIZAL SAMUEL CHANDRAKUMAR;HWANG-FUN LU |
| 分类号 |
A61K31/4245;A61K31/4375;A61K31/4439;A61K31/444;A61K31/4545;A61K31/4709;A61K31/496;A61K31/5383;A61P3/14;A61P9/00;A61P9/08;A61P9/10;A61P19/02;A61P19/10;A61P21/00;A61P27/02;A61P35/00;A61P43/00;C07D213/74;C07D231/38;C07D233/60;C07D233/88;C07D405/12;C07D413/06;C07D413/12;C07D413/14;C07D417/12;C07D471/04;C07D498/04 |
主分类号 |
A61K31/4245 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
