发明名称 |
A recombinant non-replicating virus expressing GM-CSF and uses thereof to enhance immune responses |
摘要 |
Replication-defective recombinant poxvirus encoding granulocyte-macrophage colony-stimulating factor (GM-CSF) are disclosed for use in enriching an immunization site with antigen-presenting cells (APC), for enhancing an immunological response to antigen or immunlogical epitopes by functioning as a biological adjuvant, for prevention or treatment of neutropenia, and for the treatment of myeloidysplastic syndromes. Compositions comprising a replication-defective recombinant virus encoding GM-CSF alone or in combination with a recombinant virus encoding an antigen and optionally encoding an immunostimulatory molecule are disclosed for enhancing antigen-specific immunological responses, in particular enhancing tumor antigen responses for anti-tumor therapy. Methods for enriching an immunization site with APC and for enhancing immunological responses to an antigen or immunological epitope using replication-defective recombinant poxvirus encoding GM-CSF are disclosed. The superiority of the use of a replication-defective recombinant avian poxvirus encoding GM-CSF over the use of recombinant GM-CSF is described. |
申请公布号 |
AU6845201(A) |
申请公布日期 |
2001.12.24 |
申请号 |
AU20010068452 |
申请日期 |
2001.06.15 |
申请人 |
THE GOVERNEMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED;THERION BIOLOGICS CORPORATION |
发明人 |
JEFFREY SCHLOM;JOHN W. GREINER;ERIK KASS;DENNIS PANICALI |
分类号 |
C12N15/09;A61K35/12;A61K35/14;A61K35/26;A61K35/28;A61K35/34;A61K35/76;A61K38/00;A61K38/18;A61K38/22;A61K39/00;A61K39/002;A61K39/02;A61K39/04;A61K39/05;A61K39/07;A61K39/08;A61K39/09;A61K39/095;A61K39/10;A61K39/102;A61K39/112;A61K39/118;A61K39/12;A61K39/145;A61K39/21;A61K39/245;A61K39/39;A61K39/395;A61K45/00;A61K48/00;A61P7/00;A61P31/00;A61P31/04;A61P31/10;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/00;A61P33/02;A61P35/00;A61P35/02;A61P35/04;A61P37/04;A61P41/00;A61P43/00;C07K14/535;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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