发明名称 Ceramide kinase and dna encoding the same
摘要 The present invention provides a novel protein having ceramide kinase activity which can be a target for a prophylactic or therapeutic medicament against neuronal disease, inflammation, HIV infection, type 2 diabetes mellitus, obesity, septicemia, arteriosclerosis and cancer. Specifically, a protein which comprises an amino acid sequence shown in the amino acid numbers 1-537 of SEQ ID No. 2 of the Sequencing Listing, a DNA which encodes the protein, a recombinant vector comprising the DNA, a host cell transformed with the recombinant vector, a method for producing the protein, and utilities of the protein are provided. By using the method of the present invention, a novel compound is provided having a specifically activating or inhibiting activity to ceramide kinase and useful as a medicament for treating neuronal disorder, an anti-inflammatory medicament, a medicament for treating HIV infection, an anti-type 2 diabetes mellitus medicament, an anti-obesity medicament, an anti-septicemia medicament, an anti-arteriosclerosis medicament, and an anticancer medicament.
申请公布号 AU6273401(A) 申请公布日期 2001.12.24
申请号 AU20010062734 申请日期 2001.06.11
申请人 SANKYO COMPANY LIMITED 发明人 MASAKO SUGIURA;KEITA KONO;TAKAFUMI KOHAMA
分类号 A61K31/7125;A61P3/04;A61P3/10;A61P7/00;A61P25/00;A61P29/00;A61P31/18;A61P35/00;C12N1/21;C12N9/12;C12N15/54 主分类号 A61K31/7125
代理机构 代理人
主权项
地址