Dihydro indolone derivatives having affinity for arginine-vasopressin receptor sites, useful for treatment of for e.g. cardiovascular, central nervous system disorders, renal and gastric disorders and diabetes.

摘要

Preparation of 1,3-Dihydro-2H-indol-2-one derivatives (I), their solvates, hydrates, and optical isomers. 1,3-Dihydro-2H-indolone derivatives (I), their solvates, hydrates, and optical isomers n = 1 or 2; W = O or S; R1 = hal, 1-4C alkyl or alkoxy, CF3, or CF3O; R2 = H, hal, 1-4C alkyl or alkoxy, or CF3, or R2 is in the -6-position of the indol-2-one ring and R1 and R2 together form trimethylene; R3 = halogen, OH, methyl, ethyl, methoxy, ethoxy or CF3O; R4 = H, hal, methyl, ethyl, methoxy, or ethoxy, or R3 is in the -2-position of the phenyl group, R4 is in the -3-position, and together R3 and R4 form methylene dioxy; R5 = ethylamino, dimethylamino, azetidin-1-yl, methoxy or ethoxy; R6 and R7 = 1-4C alkoxy Independent claim covers intermediates of formula (II), their salts with acids, their optical isomers and racemic mixtures.