摘要 |
<p>Compounds of the general formula [I] which inhibit nociceptin by their high affinity for nociceptin receptor and are effective in relief of pain; counteraction against narcotic analgesic tolerance; relief and prevention of obesity; improvement of cerebral functions; prevention of Alzheimer's disease; relief and prevention of dementia; treatment of schizophrenia, Parkinson's disease, and chorea; relief and prevention of depression; treatment of diabetes insipidus, polyuria, and hypotension; and so on: [|] wherein A, B, C, D and E are each an optionally substituted methine group or nitrogen; R1 is optionally substituted lower alkyl, a carbocyclic group, a heterocyclic group, or the like; n is 1 or 2; and Cy is an optionally substituted mono-, bi- or tri-cyclic aliphatic carbocyclic group having 5 to 15 carbon atoms.</p> |