BILIRUBIN OR BILIVERDIN DEGRADATION FRAGMENTS

摘要

A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y<1> is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO2R<4>, -CO2R<4>, -CONHR<4> or -COR<4>, and each of R<1>, R<2> and R<4>, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y<2> and Y<3>, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO2R<9>, -CO2R<9>, -CONHR<9> or -COR<9>, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, -CH=C(NHR<10>)CH((CH2)mCO2R<11>)(C=O)CH3 or -CH2(C=O)CH((CH2)mCO2R<11>)(C=O)CH3, R<8> is -(CH2)nCO2R<12>, each of R<5> to R<7> and R<9> to R<12>, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y<4> to Y<6>, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, -SO2R<19>, -CO2R<19>, -CONHR<19> or -COR<19>, each of R<16> and R<17>, which may be the same or different, is -(CH2)pCO2R<20>, each of R<13> TO R<15> and R<18> to R<20>, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent.