摘要 |
A compound of the formula (i) wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof for the treatment of diseases states associated with proteins which mediate cellular activity, for example by inhibiting TNF and/or PDEIV.
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申请人 |
DARWIN DISCOVERY LIMITED |
发明人 |
DYKE, HAZEL, JOAN;FINDLAY, ALAN, HAUGHAN;LOWE, CHRISTOPHER;BUCKLEY, GEORGE, MARTIN;DAVENPORT, RICHARD, JOHN;SHARPE, ANDREW;KENDALL, HANNAH, JAYNE;SABIN, VERITY, MARGARET;MONTANA, JOHN, GARY;PICKEN, CATHERINE, LOUISE |