Association of mhc class ii alleles and cancer

摘要

Particular HLA alleles are found to be associated with human cancer Some HLA alleles are negatively associated with cancer, whereas others show a positive association. This discovery suggests that the immune system plays an important role in the detection and elimination of human tumors. The invention includes methods of determining susceptibility to cancer as well as prognosis. The invention further includes methods of treatment of cancer wherein expression of a particular HLA allele is modulated.