发明名称 |
Cartilage replacement, useful particularly for repairing joint defects, comprises differentiated and proliferating chondrocytes in collagen-based biomatrix |
摘要 |
Cartilage replacement (A) prepared by (i) incorporating dedifferentiated cartilage cells (B) into a three-dimensional, gel-like biomatrix containing at least 1.5 mg/ml collagen in buffered, serum-containing cell culture medium and (ii) culturing (B) so that they redifferentiate and/or replicate to a form a transplantable (A). Independent claims are also included for the following: (a) similar material in which the biomatrix is seeded with differentiated (B) and these cultured for replication, while remaining differentiated; (b) similar material in which (B) are checked for function, morphology and/or differentiation status simultaneously with production of (A) or afterwards; and (c) biomatrix for culturing cells, particularly (B).
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申请公布号 |
DE10062626(A1) |
申请公布日期 |
2001.12.13 |
申请号 |
DE20001062626 |
申请日期 |
2000.12.15 |
申请人 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. |
发明人 |
DIETERICH, CHRISTOPH;RUPP, STEFFEN;NOLL, MICHAELA;GRAEVE, THOMAS |
分类号 |
A61K35/12;A61L27/24;A61L27/38;A61L27/60;C12N5/00;C12N5/071;C12N5/077;G01N33/50;(IPC1-7):C12N11/02 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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