METHOD USED FOR TRANSFORMING THE CARBONYL FUNCTION IN POSITION 4'' OF A CLADINOSE UNIT OF AN AZA MACROLIDE INTO AN AMINE DERIVATIVE

摘要

The invention concerns a method for preparing a compound of general formula (I) by reducing amination of a corresponding (4'')-carbonyl derivative. The invention is characterised in that it consists in: bringing said (4'')-carbonyl derivative into the presence of at least a nitrogenous reagent and a Lewis acid in conditions suited for transforming the cabonyl 4'' function; reducing the resulting mixture using a reducing agent; and optionally deprotecting the hydroxide function in position 2', to lead to the expected compound of general formula (I).