EXCITATORY AMINO ACID RECEPTOR MODULATORS

摘要

Compounds of the formula (I) in which: R<1> is (CH2)nY; n is 1 or 2; Y is NHSO2R<2> or X<1>-W-X<2>-R<3>; X<1> is O or NH; W is C=O, C=S, C=NH, or SO2; X<2> is O or NH, provided that X<1> and X<2> are not both O; R<2> is C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl or C3-8-cycloalkyl-C1-10 alkyl; and R<3> is hydrogen, C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl; or C3-8-cycloalkyl-C1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.