| 摘要 |
The disclosure provides, in certain embodiments, yeast strains that over-express a polo-box domain from Cdc5 or Plk and thereby exhibit a cytokinesis-defective, chaining growth pattern. These strains, and equivalent cell lines from other species, can be used to identify compounds that modulate polo-like kinase activity. Also described are methods of using polo-box related peptides, and polo-like kinase activity modulatory compounds, to inhibit or enhance cellular proliferation. These peptides and compounds can, for instance, be used to treat a hyper-proliferative disease, disorder or condition, such as neoplasm, through inhibition of polo kinase(s). |
