PROLONGED RELEASE MICROSPHERES FOR INJECTION DELIVERY AND PREPARATION METHOD

摘要

The invention concerns microspheres for injection delivery comprising a protein active principle and an agent coating the active principle, designed to prolong its release, free of any trace of organic solvent, and obtainable by a coating method which involves contacting under agitation the active principle with the coating agent in a supercritical fluid, said coating agent being soluble in the supercritical fluid. The protein active principle is not denatured.